Research Projects in The Churchill Group:
My current research is focused on genomic prediction of complex phenotypes using mouse resources including inbred strains and outbred mice. I am developing new linear mixed-effects models to account for kinship in heritability estimation and genetic mapping. These methods are being applied to a 72 inbred strain survey of 34 metabolic phenotypes and to a large population of Diversity Outbred (DO) mice. My long-term objective is to develop new analytical tools for understanding the genetic architecture of complex traits. Toward this end, I am currently investigating the properties of different genomic prediction methods such as LASSO, ridge regression and Bayesian inference using data from inbred strains and DO mice.