Gene Expression

Datasets Available to Download ( alphabetical order by first author )

Liver expression of B6.C3H-6T (6T) (congenic mice with low serum IGF-1) and C57BL/6J mice

Ackert-Bicknell CL, Demissie S, Marín de Evsikova C, Hsu YH, DeMambro VE, Karasik D, Cupples LA, Ordovas JM, Tucker KL, Cho K, Canalis E, Paigen B, Churchill GA, Forejt J, Beamer WG, Ferrari S, Bouxsein ML, Kiel DP, Rosen CJ.
PPARG by dietary fat interaction influences bone mass in mice and humans
J Bone Miner Res. 2008 Sep; 23(9):1398-408.

Femurs of C57BL/6J and C3H/HeJ mice on low fat diet or low fat with Rosiglitazone diet [ login ]

Ackert-Bicknell CL, Shockley KR, Horton LG, Lecka-Czernik B, Churchill GA, Rosen CJ.
Strain-specific effects of rosiglitazone on bone mass, body composition, and serum insulin-like growth factor-I
Endocrinology. 2009 Mar;150(3):1330-40.

Two designed experiments (latin square and reference sample) that used independent arrays to study the same tissue samples

Kerr MK, Martin M, Churchill GA.
Analysis of variance for gene expression microarray data
J Comput Biol. 2000;7(6):819-37.

PPARgamma2 gene expression signature in U-33 / gamma2 and U-33/c mouse cell lines

Lecka-Czernik B, Ackert-Bicknell C, Adamo ML, Marmolejos V, Churchill GA, Shockley KR, Reid IR, Grey A, Rosen CJ.
Activation of peroxisome proliferator-activated receptor gamma (PPARgamma) by rosiglitazone suppresses components of the insulin-like growth factor regulatory system in vitro and in vivo
Endocrinology. 2007 Feb;148(2):903-11.PMCID: PMC1851001 [ PDF ]

Shockley KR, Lazarenko OP, Czernik PJ, Rosen CJ, Churchill GA, Lecka-Czernik B.
PPARgamma2 nuclear receptor controls multiple regulatory pathways of osteoblast differentiation from marrow mesenchymal stem cells
J Cell Biochem. 2009 Feb 1;106(2):232-46. PMC2631627 [Available on 2010/02/01]

Shockley KR, Rosen CJ, Churchill GA, Lecka-Czernik B.
PPARgamma2 Regulates a Molecular Signature of Marrow Mesenchymal Stem Cells
PPAR Res. 2007;2007:81219. PMCID: PMC2234088 [ PDF ]

Temporal gene expression differences in mouse brain during sleep

Mackiewicz M, Shockley KR, Romer MA, Galante RJ, Zimmerman JE, Naidoo N, Baldwin DA, Jensen ST, Churchill GA, Pack AI.
Macromolecule biosynthesis: a key function of sleep
Physiol Genomics. 2007 Nov 14;31(3):441-57. [ PDF ]

Overexpression of innate immune response genes in a model of recessive polycystic kidney disease

Mrug M, Zhou J, Woo Y, Cui X, Szalai AJ, Novak J, Churchill GA, Guay-Woodford LM.
Overexpression of innate immune response genes in a model of recessive polycystic kidney disease
Kidney Int. 2008 Jan;73(1):63-76.

Gene expression analysis of B.A chromosome substitution strains

Shockley KR, Churchill GA.
Gene expression analysis of mouse chromosome substitution strains
Mamm Genome. 2006 Jun;17(6):598-614.

Gene expression and proteomics analysis from a NZB X SM F2 cross

Stylianou IM, Affourtit JP, Shockley KR, Wilpan RY, Abdi FA, Bhardwaj S, Rollins J, Churchill GA, Paigen B.
Applying gene expression, proteomics and single-nucleotide polymorphism analysis for complex trait gene identification
Genetics. 2008 Mar;178(3):1795-805. PMCID: PMC2278051 [ PDF ]

Cross platform comparison: variability in measured gene expression levels associated with three types of microarray platforms

Woo Y, Affourtit J, Daigle S, Viale A, Johnson K, Naggert J, Churchill G.
A comparison of cDNA, oligonucleotide, and Affymetrix GeneChip gene expression microarray platforms
J Biomol Tech. 2004 Dec;15(4):276-84. PMCID: PMC2291701. [ PDF ]

Design of Three- and Four-Color Microarray Experiments

Woo Y, Krueger W, Kaur A, Churchill G.
Experimental design for three-color and four-color gene expression microarrays
Bioinformatics. 2005 Jun;21 Suppl 1:i459-67.

Affymetrix expression data used to estimate p-values in small microarray experiments

Yang H, Churchill G.
Estimating p-values in small microarray experiments
Bioinformatics. 2007 Jan 1;23(1):38-43.

Dynamic gene expression changes during sleep in Drosophila brain

Zimmerman JE, Rizzo W, Shockley KR, Raizen DM, Naidoo N, Mackiewicz M, Churchill GA, Pack AI.
Multiple mechanisms limit the duration of wakefulness in Drosophila brain
Physiol Genomics. 2006 Nov 27;27(3):337-50. [ PDF ]