Temporal gene expression differences in mouse brain during sleep


Changes in gene expression in the cerebral cortex and hypothalamus were assessed following different durations of sleep and periods of sleep deprivation. Experiments were performed in male mice (C57BL/6J) at 10 wk of age ± 1 wk. The study consisted of 4 times points (3-, 6-, 9-, and 12-hrs) and a time=0 anchor point with 5 animals per condition. For further details, see Mackiewicz et al., 2007.


Macromolecule biosynthesis: a key function of sleep
Mackiewicz M, Shockley KR, Romer MA, Galante RJ, Zimmerman JE, Naidoo N, Baldwin DA, Jensen ST, Churchill GA, Pack AI.
Physiol Genomics 2007 31(3):441-57. [ Full Text ]


RMA processed data file - Cerebral Cortex
RMA processed data file - Hypothalamus
Experimental design file