Design of Three- and Four-Color Microarray Experiments
Three-color microarrays, compared with two-color microarrays, can increase design efficiency and power to detect differential expression without additional samples and arrays. To demonstrate the performance of three-color microarrays compared to two-color microarrays, experiments comparing gene expression between liver samples from three groups: A/J, C57BL/6J, and F1 hybrids, were performed in parallel using both two- and three-color platforms.
Woo Y, Krueger W, Kaur A, Churchill G.
Experimental design for three-color and four-color gene expression microarrays
Bioinformatics. 2005 Jun;21 Suppl 1:i459-67. [ Full Text ]
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