Datasets Available to Download (alphabetical order by first author)

Identification of QTL for locomotor activation and anxiety using related inbred strains C57BL/6J and C58/J [ datasets ]

Identification of QTL for locomotor activation and anxiety using closely-related inbred strains
Bailey JS, Grabowski-Boase L, Steffy BM, Wiltshire T, Churchill GA, Tarantino LM.
Genes Brain Behav. 2008 Oct;7(7):761-9.

Bone mineral density and IGF-1 levels in F2 progeny from a C57BL/6J x C3H/HeJ intercross [ datasets ]

Quantitative trait loci for femoral and lumbar vertebral bone mineral density in C57BL/6J and C3H/HeJ inbred strains of mice
Beamer WG, Shultz KL, Donahue LR, Churchill GA, Sen S, Wergedal JR, Baylink DJ, Rosen CJ.
J Bone Miner Res. 2001 Jul;16(7):1195-206.

Mapping quantitative trait loci for serum insulin-like growth factor-1 levels in mice
Rosen CJ, Churchill GA, Donahue LR, Shultz KL, Burgess JK, Powell DR, Beamer WG.
Bone. 2000 Oct;27(4):521-8.

Bone mineral density in F2 progeny from a C57BL/6J x CAST/EiJ intercross [ datasets ]

Quantitative trait loci for bone density in C57BL/6J and CAST/EiJ inbred mice
Beamer WG, Shultz KL, Churchill GA, Frankel WN, Baylink DJ, Rosen CJ, Donahue LR.
Mamm Genome. 1999 Nov;10(11):1043-9.

Gut length in a mouse intercross between C3HeBFeJ (C3) and C57BL/6J (B6), with one F1 parent carrying the Sox10Dom mutation [ datasets ]

The X chromosome in quantitative trait locus mapping
Broman KW, Sen S, Owens SE, Manichaikul A, Southard-Smith EM, Churchill GA.
Genetics. 2006 Dec;174(4):2151-8. PMCID: PMC1698653. [ PDF ]

UV-induced immunosuppression in backcross mice (involving BALB/cAnNCrl and C57BL/6NCrl) [ datasets ]

Genetic control of susceptibility to UV-induced immunosuppression by interacting quantitative trait loci
Clemens KE, Churchill G, Bhatt N, Richardson K, Noonan FP.
Genes Immun. 2000;1(4):251-9. [ PDF ]

Blood pressure in a F2 progeny from C3H x SWR intercross [ datasets ]

Genetic analysis of blood pressure in C3H/HeJ and SWR/J mice
DiPetrillo K, Tsaih SW, Sheehan S, Johns C, Kelmenson P, Gavras H, Churchill GA, Paigen B.
Physiol Genomics. 2004 Apr 13;17(2):215-20.

Albuminuria QTL and the the presence and absence of Apoe in mouse crosses [ datasets ]

Quantitative trait loci for urinary albumin in crosses between C57BL/6J and A/J inbred mice in the presence and absence of Apoe
Doorenbos C, Tsaih SW, Sheehan S, Ishimori N, Navis G, Churchill G, Dipetrillo K, Korstanje R.
Genetics. 2008 May;179(1):693-9. PMCID: PMC2390645. [ PDF ]

Ovarian granulosa cell tumors in F2 progeny from the SWXJ-9 x CAST/Ei intercross [ datasets ]

Distal Chr 4 harbors a genetic locus (Gct1) fundamental for spontaneous ovarian granulosa cell tumorigenesis in a mouse model
Dorward AM, Shultz KL, Horton LG, Li R, Churchill GA, Beamer WG.
Cancer Res. 2005 Feb 15;65(4):1259-64. [ PDF ]

Kidney parameters predicting renal cystic disease severity in F2 progeny of BALB/c-Bicc1jcpk-bpk and CAST/EiJ [ datasets ]

Quantitative trait loci modulate renal cystic disease severity in the mouse bpk model
Guay-Woodford LM, Wright CJ, Walz G, Churchill GA.
J Am Soc Nephrol. 2000 Jul;11(7):1253-60. [ PDF ]

Plasma HDL cholesterol, obesity, and atherosclerosis susceptibility in F2 progeny from a C57BL/6J x 129S1/SvImJ intercross [ datasets ]

Quantitative trait loci analysis for plasma HDL-cholesterol concentrations and atherosclerosis susceptibility between inbred mouse strains C57BL/6J and 129S1/SvIm
Ishimori N, Li R, Kelmenson PM, Korstanje R, Walsh KA, Churchill GA, Forsman-Semb K, Paigen B.
J. Arterioscler Thromb Vasc Biol 24:161-166. [ PDF ]

Quantitative trait loci that determine plasma lipids and obesity in C57BL/6J and 129S1/SvImJ inbred mice
Ishimori N, Li R, Kelmenson PM, Korstanje R, Walsh KA, Churchill GA, Forsman-Semb K, Paigen B.
J Lipid Res 45(9):1624-1632. [ PDF ]

Genetic modifiers affecting ear and eye phenotypes of jag1 heterozygous mice [ datasets ]

Genetic background modifies inner ear and eye phenotypes of jag1 heterozygous mice
Kiernan AE, Li R, Hawes NL, Churchill GA, Gridley T.
Genetics. 2007 Sep;177(1):307-11. PMCID: PMC2013712 [ PDF ]

HDL cholesterol and phospholipid transfer activity (PLTP) in F2 progeny from an SM/J x NZB/BlNJ intercross [ datasets ]

Quantitative trait locus mapping of genes that regulate phospholipid transfer activity in SM/J and NZB/BlNJ inbred mice
Korstanje R, Albers JJ, Wolfbauer G, Li R, Tu AY, Churchill GA, Paigen BJ.
Arterioscler Thromb Vasc Biol. 2004 Jan;24(1):155-60. [ PDF ]

Influence of sex and diet on quantitative trait loci for HDL cholesterol levels in an SM/J by NZB/BlNJ intercross population
Korstanje R, Li R, Howard T, Kelmenson P, Marshall J, Paigen B, Churchill G.
J Lipid Res. 2004 May;45(5):881-8. [ PDF ]

Food intake volume in F2 progeny from the B6.CAST-17 and CAST/Ei intercross [ datasets ]

Genetic variation in Glp1r expression influences the rate of gastric emptying in mice
Kumar KG, Byerley LO, Volaufova J, Drucker DJ, Churchill GA, Li R, York B, Zuberi A, Richards BK.
Am J Physiol Regul Integr Comp Physiol. 2008 Feb;294(2):R362-71. [ PDF ]

NOD x 129.H2g7 Backcross Delineates 129S1/SvImJ-Derived Genomic Regions Modulating Type 1 Diabetes (T1D) Development In Mice [ datasets ]

NOD x 129.H2g7 Backcross Delineates 129S1/SvImJ-Derived Genomic Regions Modulating Type 1 Diabetes (T1D) Development In Mice
Leiter EH, Reifsnyder PC, Wallace R, Li R, King B, Churchill GC.
Diabetes. 2009 Mar 31. [ PDF ]

Plasma lipids and susceptibility to gallstones in F2 progeny of DBA/2J x CAST/EiJ [ datasets ]

Quantitative trait loci that determine lipoprotein cholesterol levels in DBA/2J and CAST/Ei inbred mice
Lyons MA, Wittenburg H, Li R, Walsh KA, Churchill GA, Carey MC, Paigen B.
J Lipid Res. 2003 May;44(5):953-67. [ PDF ]

Lith6: a new QTL for cholesterol gallstones from an intercross of CAST/Ei and DBA/2J inbred mouse strains
Lyons MA, Wittenburg H, Li R, Walsh KA, Leonard MR, Korstanje R, Churchill GA, Carey MC, Paigen B.
J Lipid Res. 2003 Sep;44(9):1763-71. [ PDF ]

Gallstone susceptibility in F2 progeny of NZB/BlNJ and SM/J [ datasets ]

Single and interacting QTLs for cholesterol gallstones revealed in an intercross between mouse strains NZB and SM
Lyons MA, Korstanje R, Li R, Sheehan SM, Walsh KA, Rollins JA, Carey MC, Paigen B, Churchill GA.
Mamm Genome. 2005 Mar;16(3):152-63.

Gallstone susceptibility in F2 progeny of 129/SvImJ and CAST/EiJ [ datasets ]

New quantitative trait loci that contribute to cholesterol gallstone formation detected in an intercross of CAST/Ei and 129S1/SvImJ inbred mice
Lyons MA, Wittenburg H, Li R, Walsh KA, Leonard MR, Churchill GA, Carey MC, Paigen B.
Physiol Genomics. 2003 Aug 15;14(3):225-39.

Subphenotypes of colitis susceptibility in IL-10-deficient mice generated from backcrosses involving C3H/HeJBir and C57BL/6J [ datasets ]

Genetics of colitis susceptibility in IL-10-deficient mice: backcross versus F2 results contrasted by principal component analysis
Mahler M, Most C, Schmidtke S, Sundberg JP, Li R, Hedrich HJ, Churchill GA.
Genomics. 2002 Sep;80(3):274-82.

Blood pressure in a F2 progeny from C3H x NZO and NZOxC3H intercross populations [ datasets ]

Quantitative trait loci associated with blood pressure of metabolic syndrome in the progeny of NZO/HILtJ x C3H/HeJ intercrosses
Nishihara E, Tsaih SW, Tsukahara C, Langley S, Sheehan S, Dipetrillo K, Kunita S, Yagami K, Churchill GA, Paigen B, Sugiyama F.
Mamm Genome. 2007 Aug;18(8):573-83.

Hematologic data for F2 progeny of C3H/HeJ+/wan x CAST/EiJ [ datasets ]

Identification of quantitative trait loci that modify the severity of hereditary spherocytosis in wan, a new mouse model of band-3 deficiency
Peters LL, Swearingen RA, Andersen SG, Gwynn B, Lambert AJ, Li R, Lux SE, Churchill GA.
Blood. 2004 Apr 15;103(8):3233-40. [ PDF ]

Plasma HDL cholesterol regulation in backcross progeny involving NZB/BlNJ and SM/J [ datasets ]

Quantitative trait locus mapping of genes that regulate HDL cholesterol in SM/J and NZB/B1NJ inbred mice
Pitman WA, Korstanje R, Churchill GA, Nicodeme E, Albers JJ, Cheung MC, Staton MA, Sampson SS, Harris S, Paigen B.
Physiol Genomics. 2002;9(2):93-102. [ PDF ]

Age-related body weight and composition, plasma glucose, insulin, and leptin in backcross mice (involving NZO/HlLtJ and NON/ShiLtJ) [ datasets ]

Maternal environment and genotype interact to establish diabesity in mice
Reifsnyder PC, Churchill G, Leiter EH.
Genome Res 10:1568-1578. PMCID: PMC310941. [ PDF ]

Type 1 diabetes in the intercross of NOD mice and a 'genome-conditioned' NOR stock [ datasets ]

Conditioning the genome identifies additional diabetes resistance loci in Type I diabetes resistant NOR/Lt mice
Reifsnyder PC, Li R, Silveira PA, Churchill G, Serreze DV, Leiter EH.
Genes Immun. 2005 Sep;6(6):528-38.

Conditioning the genome identifies additional diabetes resistance loci in Type 1 diabetes-resistant NOR/Lt mice
Reifsnyder PC, Li R, Silveira PA, Churchill G, Serreze DV, Leiter EH.
Genes Immun. 2006 Mar;7(2):184.

Urinary albumin concentration in a F2 male mice from C57BL/6J x DBA/2J intercross [ datasets ]

Genetic analysis of albuminuria in a cross between C57BL/6J and DBA/2J mice
Sheehan S, Tsaih SW, King BL, Stanton C, Churchill GA, Paigen B, DiPetrillo K.
Am J Physiol Renal Physiol 2007 293(5):F1649-56. [ PDF ]

Fat, carbohydrate, and calorie intake for F2 reciprocal crosses involving C57BL/6J and CAST/EiJ on a self-selected macronutrient diet [ datasets ]

QTL analysis of self-selected macronutrient diet intake: fat, carbohydrate, and total kilocalories
Smith Richards BK, Belton BN, Poole AC, Mancuso JJ, Churchill GA, Li R, Volaufova J, Zuberi A, York B.
Physiol Genomics. 2002 Dec 3;11(3):205-17. [ PDF ]

Weight and distribution of fat pads in F2 progeny of SM/J x NZB/BlNJ [ datasets ]

Quantitative trait locus analysis for obesity reveals multiple networks of interacting loci
Stylianou IM, Korstanje R, Li R, Sheehan S, Paigen B, Churchill GA.
Mamm Genome. 2006 Jan;17(1):22-36.

HDL in B.A CSS and F2 mouse crosses [ datasets ]

Complex genetic architecture revealed by analysis of high-density lipoprotein cholesterol in chromosome substitution strains and f2 crosses
Stylianou IM, Tsaih SW, Dipetrillo K, Ishimori N, Li R, Paigen B, Churchill G.
Genetics. 2006 Oct;174(2):999-1007. PMCID: PMC1602087 [ PDF ]

Blood pressure in males of reciprocal backcrosses between C57BL/6J (salt-sensitive) and A/J (non-salt-sensitive) [ datasets ]

Concordance of murine quantitative trait loci for salt-induced hypertension with rat and human loci
Sugiyama F, Churchill GA, Higgins DC, Johns C, Makaritsis KP, Gavras H, Paigen B.
Genomics. 2001 Jan 1;71(1):70-7.

Blood pressure and heart rate in males of F2 progeny of BALB/cJ and CBA/CaJ [ datasets ]

QTL associated with blood pressure, heart rate, and heart weight in CBA/CaJ and BALB/cJ mice
Sugiyama F, Churchill GA, Li R, Libby LJ, Carver T, Yagami K, John SW, Paigen B.
Physiol Genomics. 2002 Jul 12;10(1):5-12.

Alopecia Areata in F2 progeny in a C3H/HeJ x C57BL/6J intercross [ datasets ]

Major locus on mouse chromosome 17 and minor locus on chromosome 9 are linked with alopecia areata in C3H/HeJ mice
Sundberg JP, Boggess D, Silva KA, McElwee KJ, King LE, Li R, Churchill G, Cox GA.
J Invest Dermatol. 2003 May;120(5):771-5. [ PDF ]

QTL mapping in recombinant inbred intercross (RIX) hybrids [ datasets ]

Quantitative trait mapping in a diallel cross of recombinant inbred lines
Tsaih SW, Lu L, Airey DC, Williams RW, Churchill GA.
Mamm Genome. 2005 May;16(5):344-55.

Plasma HDL cholesterol and atherosclerosis susceptibility in progeny from advanced intercross lines (AILs) involving C57BL/6J and NZB/BlNJ [ datasets ]

Using advanced intercross lines for high-resolution mapping of HDL cholesterol quantitative trait loci
Wang X, Le Roy I, Nicodeme E, Li R, Wagner R, Petros C, Churchill GA, Harris S, Darvasi A, Kirilovsky J, Roubertoux PL, Paigen B.
Genome Res. 2003 Jul;13(7):1654-64. PMCID: PMC403739. [ PDF ]

Plasma HDL cholesterol and atherosclerosis susceptibility in backcross progeny involving C57BL/6J and NZB/BlNJ [ datasets ]

Using advanced intercross lines for high-resolution mapping of HDL cholesterol quantitative trait loci
Wang X, Le Roy I, Nicodeme E, Li R, Wagner R, Petros C, Churchill GA, Harris S, Darvasi A, Kirilovsky J, Roubertoux PL, Paigen B.
Genome Res. 2003 Jul;13(7):1654-64. PMCID: PMC403739. [ PDF ]

Bone Mineral Density (BMD) and related bone phenotypes in a NZB/B1NJ and RF/J F2 intercross [ datasets ]

Femur mechanical properties in the F2 Progeny of an NZB/B1NJ x RF/J cross are regulated predominantly by genetic loci that regulate bone geometry
Wergedal JE, Ackert-Bicknell CL, Tsaih S-W, Sheng M H-C, Li R, Mohan S, Beamer WG, Churchill GA, Baylink DJ. 2006.
J Bone Miner Res. 2006 Aug;21(8):1256-66

Cholesterol gallstones, gallbladder mucin accumulation, and related gallstone phenotypes in reciprocal backcrosses between AKR/J and SWR/J [ datasets ]

Interacting QTLs for cholesterol gallstones and gallbladder mucin in AKR and SWR strains of mice
Wittenburg H, Lammert F, Wang DQ, Churchill GA, Li R, Bouchard G, Carey MC, Paigen B.
Physiol Genomics. 2002 Feb 11;8(1):67-77.

Cholesterol gallstone formation in reciprocal backcrosses between PERA/EiJ and I/LnJ [ datasets ]

FXR and ABCG5/ABCG8 as determinants of cholesterol gallstone formation from quantitative trait locus mapping in mice
Wittenburg H, Lyons MA, Li R, Churchill GA, Carey MC, Paigen B.
Gastroenterology. 2003 Sep;125(3):868-81.

Plasma lipids, cholesterol gallstones, and related gallstone phenotypes in an intercross between DBA/2J and PERA/EiJ [ datasets ]

Association of a lithogenic Abcg5/Abcg8 allele on Chromosome 17 (Lith9) with cholesterol gallstone formation in PERA/EiJ mice
Wittenburg H, Lyons MA, Li R, Kurtz U, Mossner J, Churchill GA, Carey MC, Paigen B.
Mamm Genome. 2005 Jul;16(7):495-504.

Plasma lipids in F2 progenies from the PERA/EiJxI/LnJ and PERA/EiJxDBA/2J intercrosses [ datasets ]

QTL mapping for genetic determinants of lipoprotein cholesterol levels in combined crosses of inbred mouse strains
Wittenburg H, Lyons MA, Li R, Kurtz U, Wang X, Mossner J, Churchill GA, Carey MC, Paigen B.
J Lipid Res. 2006 Aug;47(8):1780-90. [ PDF ]