Bone mineral density and IGF-1 levels in F2 progeny from a C57BL/6J x C3H/HeJ intercross

Description

An intercross of C3H/HeJ and C57BL/6J was generated to identify quantitative trait loci (QTL) for serum insulin-like growth factor-1 (IGF-1) levels and bone-related phenotypes. F2 females were tested for IGF-1 and analyzed for femur bone mineral density (BMD), strength, and geometry. For detailed protocols see Beamer et al., 2001 and Rosen et al., 2000.

Please note that only files prefixed with '37' have had the mit marker positions translated to the Shifman Build 37.

Reference

Beamer WG, Shultz KL, Donahue LR, Churchill GA, Sen S, Wergedal JR, Baylink DJ, Rosen CJ.
Quantitative trait loci for femoral and lumbar vertebral bone mineral density in C57BL/6J and C3H/HeJ inbred strains of mice
J Bone Miner Res. 2001 Jul;16(7):1195-206.

Rosen CJ, Churchill GA, Donahue LR, Shultz KL, Burgess JK, Powell DR, Beamer WG.
Mapping quantitative trait loci for serum insulin-like growth factor-1 levels in mice
Bone. 2000 Oct;27(4):521-8.

Datasets


Mouse Phenome Database

Description: QTL-Beamer1.xls

Data: 37QTL-Beamer1.csv