Plasma HDL cholesterol, obesity, and atherosclerosis susceptibility in F2 progeny from a C57BL/6J x 129S1/SvImJ intercross
Description
An intercross between C57BL/6J and 129S1/SvImJ inbred mouse strains was generated to identify quantitative trait loci (QTL) involved in plasma HDL cholesterol concentrations, obesity, and susceptibility to atherosclerosis. Body and liver weight, body composition, bone mineral density, blood lipids, parathyroid hormone levels, and aortic lesion size were measured in mice administered a high-fat (15%) diet from 6-20 wks of age (14 wks on high fat diet). Plasma was obtained from fasted mice (4 hr). For detailed protocols see publications.
Please note that only files prefixed with '37' have had the mit marker positions translated to the Shifman Build 37.
Reference
Ishimori N, Li R, Kelmenson PM, Korstanje R, Walsh KA, Churchill GA, Forsman-Semb K, Paigen B.
Quantitative trait loci analysis for plasma HDL-cholesterol concentrations and atherosclerosis susceptibility between inbred mouse strains C57BL/6J and 129S1/SvIm
J. Arterioscler Thromb Vasc Biol. 2004 Jan;24(1):161-6. [ PDF ]
Ishimori N, Li R, Kelmenson PM, Korstanje R, Walsh KA, Churchill GA, Forsman-Semb K, Paigen B.
Quantitative trait loci that determine plasma lipids and obesity in C57BL/6J and 129S1/SvImJ inbred mice
J Lipid Res 2004 Sept;45(9):1624-1632. [ PDF ]
Datasets
Description: QTL-Ishimori1.xls
Data: 37QTL-Ishimori1.csv