HDL cholesterol and phospholipid transfer activity (PLTP) in F2 progeny from an SM/J x NZB/BlNJ intercross

Description

An intercross between SM/J x NZB/BlNJ inbred mouse strains was generated to identify quantitative trait loci (QTL) that are involved in regulating phospholipid transfer activity (PLTP) and HDL cholesterol levels. PLTP activity, total cholesterol, and HDL cholesterol were measured in mice administered a high-fat (15%) diet from 8-24 wks of age (16 wks on high fat diet). Plasma was obtained from fasted mice (4 hr) at 8 wks (baseline), 14, 20, and 24 wks. For detailed protocols see Korstanje publications (below).

Please note that only files prefixed with '37' have had the mit marker positions translated to the Shifman Build 37.

Reference

Korstanje R, Albers JJ, Wolfbauer G, Li R, Tu AY, Churchill GA, Paigen BJ.
Quantitative trait locus mapping of genes that regulate phospholipid transfer activity in SM/J and NZB/BlNJ inbred mice
Arterioscler Thromb Vasc Biol. 2004 Jan;24(1):155-60. [ PDF ]

Korstanje R, Li R, Howard T, Kelmenson P, Marshall J, Paigen B, Churchill G.
Influence of sex and diet on quantitative trait loci for HDL cholesterol levels in an SM/J by NZB/BlNJ intercross population
J Lipid Res. 2004 May;45(5):881-8. [ PDF ]

Datasets


Mouse Phenome Database

Description: QTL-Korstanje1.xls

Data: 37QTL-Korstanje1.csv