UV-induced immunosuppression in backcross mice (involving BALB/cAnNCrl and C57BL/6NCrl)

Description

A backcross involving BALB/cAnNCrl and C57BL/6NCrl inbred mouse strains was generated to identify quantitative trait loci (QTL) involved in UV-induced immunosuppression. Backcross progeny were tested for systemic immunosuppression of a contact hypersensitivity response. Intervention: UV radiation dose 4.5 kJ/m2 for 15 min. Sensitization: trinitrochlorobenzene (TNCB). For detailed protocols see Clemens et al., 2000.

Please note that only files prefixed with '37' have had the mit marker positions translated to the Shifman Build 37.

Reference

Clemens KE, Churchill G, Bhatt N, Richardson K, Noonan FP.
Genetic control of susceptibility to UV-induced immunosuppression by interacting quantitative trait loci
Genes Immun. 2000;1(4):251-9. [ PDF ]

Datasets


Mouse Phenome Database

Description: QTL-Clemens1.xls

Data: 37QTL-Clemens1.csv