Overexpression of innate immune response genes in a model of recessive polycystic kidney disease

Defects in the primary cilium/basal body complex of renal tubular cells cause polycystic kidney disease (PKD). To uncover pathways associated with disease progression, kidney transcriptome of 10-day-old severely and mildly affected cpk mice, a model of recessive PKD, were examined using Affymetrix GeneChips.